Why We Get Fat: And What to Do About It by Taubes Gary

Author:Taubes, Gary [Taubes, Gary]
Language: eng
Format: azw3, epub
ISBN: 9780307595515
Publisher: Knopf Doubleday Publishing Group
Published: 2010-12-27T16:00:00+00:00

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*To be precise, the insulin stashes fat in the fat tissue and assures that it stays there. Our muscles are forced to burn more carbohydrates to compensate, and we deplete our reserves of glycogen, which alone might make us hungrier. The result is that we want to eat more and expend less, while our fat tissue just keeps filling up with fat.

†The effect of making particular tissues insulin-resistant can be mimicked in laboratory mice and has been by researchers at the Joslin Diabetes Center in Boston. They created mice that lack what are called insulin “receptors” on different tissues, which means those tissues are completely resistant to insulin. As we’d expect, mice that lack insulin receptors on their muscle cells but not on their fat cells get obese. The animals partition glucose into the fat for storage, not the muscles for energy. Mice that lack insulin receptors on their fat cells are lean, and they stay lean, even when they’re force-fed more food than they’d otherwise prefer to eat.

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